SHP2-IN-8
Modify Date: 2025-08-27 06:52:05
SHP2-IN-8 structure
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Common Name | SHP2-IN-8 | ||
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| CAS Number | 1801692-60-3 | Molecular Weight | 398.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H21Cl2N5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SHP2-IN-8SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1]. |
| Name | SHP2-IN-8 |
|---|
| Description | SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1]. |
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| Related Catalog | |
| Target |
IC50: 23 nM (SHP2)[1] Ki: 22 nM (SHP2)[1] |
| In Vitro | SHP2-IN-8 (compound TK-453) (0-100 μM; 48 hours) has moderate inhibitory effects on the proliferation of KYSE-70, Hela and THP-1 cells[1]. SHP2-IN-8 (0-30 μM; 24 hours) induces the apoptosis of Hela cells in a concentration-dependent manner[1]. SHP2-IN-8 (0-30 μM; 0-2 hour）concentration- and time-dependently inhibits the phosphorylation of AKT in Hela and KYSE-70 cell lines[1]. Cell Proliferation Assay Cell Line: Hela, KYSE-70, THP-1[1] Concentration: 0, 1, 3, 10, 30 and 100 μM Incubation Time: 48 hours Result: Showed moderate inhibitory effects on the proliferation of KYSE-70, Hela and THP-1 cells at the concentrations of 30 and 100 μM. Apoptosis Analysis Cell Line: Hela[1] Concentration: 0, 10 and 30 μM Incubation Time: 24 hours Result: Induced the apoptosis of Hela cells in a concentration-dependent manner. Western Blot Analysis Cell Line: Hela and KYSE-70[1] Concentration: 0, 0.3, 1, 3, 10 and 30 μM; or 10 μM Incubation Time: 2 hours; or 0, 5, 10, 15, 30, 60, 120 min Result: Concentration- and time-dependently inhibited the phosphorylation of AKT in Hela and KYSE-70 cell lines. |
| References |
| Molecular Formula | C17H21Cl2N5S |
|---|---|
| Molecular Weight | 398.35 |