Vutiglabridin

Modify Date: 2024-01-11 10:28:38

Vutiglabridin Structure
Vutiglabridin structure
Common Name Vutiglabridin
CAS Number 1800188-47-9 Molecular Weight 354.44
Density N/A Boiling Point N/A
Molecular Formula C22H26O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Vutiglabridin


Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent[1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability[1].

 Names

Name Vutiglabridin

 Vutiglabridin Biological Activity

Description Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent[1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability[1].
Related Catalog
In Vivo Vutiglabridin (HSG4112) fully reverses adiposity in HFD-induced obese mice in a dose-dependent manner. Vutiglabridin (orally administered with 10, 30, or 100 mg/kg dose for 6 weeks) dose-dependently reduces body weight and normalizes obesity-related parameters in high-fat diet (HFD)-induced obese mice[2]. Animal Model: HFD-induced obese male C57BL/6J mice[2] Dosage: 10, 30, and 100 mg/kg Administration: Orally administered for 6 weeks Result: Led to significant dose-dependent body weight reduction by 4.0 g (8.3%), 10 g (21%), and 19 g (40%), respectively, compared to the 48.1 g body weight of HFD-induced obese mice administered with only the vehicle at 10, 30, and 100 mg/kg.
References

[1]. In Yong Bae, et al. Species Differences in Stereoselective Pharmacokinetics of HSG4112, A New Anti-Obesity Agent. Pharmaceutics. 2020 Feb 3;12(2):127.

[2]. Leo Sungwong Choi, et al. Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity. Int J Obes (Lond). 2021 Jan;45(1):130-142.

 Chemical & Physical Properties

Molecular Formula C22H26O4
Molecular Weight 354.44
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