E-7386
Modify Date: 2024-01-14 21:01:18
E-7386 structure
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Common Name | E-7386 | ||
|---|---|---|---|---|
| CAS Number | 1799824-08-0 | Molecular Weight | 725.85 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H48FN9O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of E-7386E-7386 is an orally active CBP/beta-catenin modulator. |
| Name | E-7386 |
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| Description | E-7386 is an orally active CBP/beta-catenin modulator. |
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| Related Catalog | |
| Target |
CBP/beta-catenin[1] |
| In Vivo | E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1]. |
| Animal Admin | The mice are treated with E-7386 (50 mg/kg, orally, BID) for three weeks. Tumor diameters are measured with digital calipers, and the tumor volume in mm3 is calculated. Immunohistochemical (IHC) analysis is evaluated for tumor-infiltrating T cells[1]. |
| References |
| Molecular Formula | C39H48FN9O4 |
|---|---|
| Molecular Weight | 725.85 |
| Storage condition | 2-8℃ |