ASTX660 hydrochloride
Modify Date: 2023-01-10 22:27:43
ASTX660 hydrochloride structure
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Common Name | ASTX660 hydrochloride | ||
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| CAS Number | 1799328-50-9 | Molecular Weight | 612.612 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H44Cl2FN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ASTX660 hydrochlorideASTX660 hydrochloride is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM; potently inhibits association between XIAP and caspase 9 in HEK293 cell line with EC50 of 2.8 nM, binds to and leads to the degradation of cIAP1/2 and stabilisation of NIK in cell; induces apoptosis in MDA-MB-231 cells with EC50 of 1.8 nM, which is TNF-α-dependent; inhibits tumor growth in mice bearing breast and melanoma tumor xenografts. Blood Cancer Phase 2 Clinical |
| Name | ASTX660 hydrochloride |
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| Description | ASTX660 hydrochloride is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM; potently inhibits association between XIAP and caspase 9 in HEK293 cell line with EC50 of 2.8 nM, binds to and leads to the degradation of cIAP1/2 and stabilisation of NIK in cell; induces apoptosis in MDA-MB-231 cells with EC50 of 1.8 nM, which is TNF-α-dependent; inhibits tumor growth in mice bearing breast and melanoma tumor xenografts. Blood Cancer Phase 2 Clinical |
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| References | References 1. Ward GA, et al. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0848.2017. View Related Products by Target IAP Blood Cancer |
| Molecular Formula | C30H44Cl2FN5O3 |
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| Molecular Weight | 612.612 |