Butyl isobutyl phthalate

Modify Date: 2024-01-03 06:24:57

Butyl isobutyl phthalate Structure
Butyl isobutyl phthalate structure
Common Name Butyl isobutyl phthalate
CAS Number 17851-53-5 Molecular Weight 278.344
Density 1.1±0.1 g/cm3 Boiling Point 315.7±10.0 °C at 760 mmHg
Molecular Formula C16H22O4 Melting Point N/A
MSDS N/A Flash Point 165.4±8.5 °C

 Use of Butyl isobutyl phthalate


Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].

 Names

Name 1-O-butyl 2-O-(2-methylpropyl) benzene-1,2-dicarboxylate
Synonym More Synonyms

 Butyl isobutyl phthalate Biological Activity

Description Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].
Related Catalog
Target

IC50: 38 μM (α-glucosidase)[1]

In Vitro Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC50 value of 38 μM[1].
In Vivo Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively[1]. Animal Model: Streptozocin induced diabetic mice (Male Kunming mice)[1] Dosage: 25, 50 or 100 mg/kg Administration: Intragastric administration Result: Had the observed antidiabetes activity in mice.
References

[1]. Bu T, et al.α-Glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid.Phytother Res. 2010 Nov;24(11):1588-91.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 315.7±10.0 °C at 760 mmHg
Molecular Formula C16H22O4
Molecular Weight 278.344
Flash Point 165.4±8.5 °C
Exact Mass 278.151794
PSA 52.60000
LogP 4.64
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.498

 Safety Information

HS Code 2917349000

 Customs

HS Code 2917349000
Summary 2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

Butyl isobutyl phthalate
Phthalic acid,butyl isobutyl ester
butyl 2-methylpropyl benzene-1,2-dicarboxylate
phtalic acid n-butyl-iso-butyl ester
EINECS 241-802-2
1,2-Benzenedicarboxylic acid, butyl 2-methylpropyl ester
butyl-2-methylpropyl phthalate
Phthalic acid, butyl isobutyl ester
1,2-benzenedicarboxylic acid,butyl 2-methylpropyl ester
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Price: ¥990/10 mM * 1 mL in DMSO

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