9-Decyn-1-ol

Modify Date: 2024-01-14 16:37:55

9-Decyn-1-ol structure	Common Name	9-Decyn-1-ol
	CAS Number	17643-36-6	Molecular Weight	154.249
	Density	0.9±0.1 g/cm3	Boiling Point	232.1±23.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	171.8±14.9 °C

Use of 9-Decyn-1-ol

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].

Name	dec-9-yn-1-ol
Synonym	More Synonyms

Description	9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].
References	[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

Density	0.9±0.1 g/cm3
Boiling Point	232.1±23.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	171.8±14.9 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.71
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.458

9-Decyn-1-ol MSDS(Chinese)

HS Code	2905290000

HS Code	2905290000
Summary	2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

10-Hydroxy-1-decyne

dec-9-yn-1-ol

9-Decyn-1-ol

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DEC-9-YN-1-OL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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