BODIPY FL prazosin

Modify Date: 2025-11-24 21:02:04

BODIPY FL prazosin structure	Common Name	BODIPY FL prazosin
	CAS Number	175799-93-6	Molecular Weight	563.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₂BF₂N₇O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BODIPY FL prazosin

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3].

Name	BODIPY FL prazosin

Description	BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	α1A-adrenergic receptor:14.5 nM (Ki) α1B-adrenergic receptor:43.3 nM (Ki)
In Vitro	BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively[1]. BODIPY FL prazosin (100 nM, 30 min) can be used as molecular probe for the Visualization of the non-adrenoceptor binding site of α1-adrenergic drugs in erythroleukemia cells[3].
References	[1]. Sugawara T, et al. Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin. Life Sci. 2002 Mar 22;70(18):2113-24. [2]. Cerveny L, et al. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia. 2006 Mar;47(3):461-8. [3]. Fuchs R, et al. α1-adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells. Exp Cell Res. 2011 Dec 10;317(20):2969-80.

Molecular Formula	C₂₈H₃₂BF₂N₇O₃
Molecular Weight	563.41

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