Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt

Modify Date: 2024-01-08 16:06:04

Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt structure	Common Name	Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt
	CAS Number	172450-46-3	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆₉H₂₇₄N₅₄O₄₈S₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt

ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].

Name	SHK
Synonym	More Synonyms

Description	ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Kv1.3 Channel[2]
References	[1]. Castañeda O, et al. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. [2]. Beeton C, et al. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11;283(2):988-97.

Molecular Formula	C₁₆₉H₂₇₄N₅₄O₄₈S₇
Storage condition	-15°C

STICHODACTYLA HELIANTHUS NEUROTOXIN (SHK)

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Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt

Use of Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt

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Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.