Estradiol 3-sulfamate
Modify Date: 2025-08-24 20:45:47
Estradiol 3-sulfamate structure
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Common Name | Estradiol 3-sulfamate | ||
|---|---|---|---|---|
| CAS Number | 172377-52-5 | Molecular Weight | 351.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H25NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Estradiol 3-sulfamateEstradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. |
| Name | Estradiol 3-sulfamate |
|---|
| Description | Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. |
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| Related Catalog | |
| Target |
IC50: 251 nM (estrone sulfatase)[1] Ki: 133 nM (estrone sulfatase)[1] |
| In Vitro | Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity[1]. |
| In Vivo | Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2]. |
| References |
| Molecular Formula | C18H25NO4S |
|---|---|
| Molecular Weight | 351.46 |
| Storage condition | 2-8℃ |