4-(3-bromoanilino)-6,7-diethoxyquinazoline

Modify Date: 2024-01-02 19:37:14

4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure
4-(3-bromoanilino)-6,7-diethoxyquinazoline structure
 Common Name 4-(3-bromoanilino)-6,7-diethoxyquinazoline
CAS Number 171745-13-4 Molecular Weight 388.26
Density 1.4±0.1 g/cm3 Boiling Point 492.6±45.0 °C at 760 mmHg
Molecular Formula C18H18BrN3O2 Melting Point N/A
MSDS N/A Flash Point 251.7±28.7 °C

 Use of 4-(3-bromoanilino)-6,7-diethoxyquinazoline


EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6[1].

 Names

Name N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine
Synonym More Synonyms

  Biological Activity

Description EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6[1].
Related Catalog
Target

EGFR:10.6 (pIC50)

References

[1]. Farhan Ahmad Pasha, et al. In silico QSAR studies of anilinoquinolines as EGFR inhibitors. J Mol Model. 2010 Feb;16(2):263-77.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 492.6±45.0 °C at 760 mmHg
Molecular Formula C18H18BrN3O2
Molecular Weight 388.26
Flash Point 251.7±28.7 °C
Exact Mass 387.058228
PSA 56.27000
LogP 5.14
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.652

 Safety Information

 Synthetic Route

3-Bromoaniline structure

3-Bromoaniline

CAS#:591-19-5

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4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure

4-(3-bromoanili...

CAS#:171745-13-4

Literature: Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
4-Chloro-6,7-dimethoxyquinazoline structure

4-Chloro-6,7-di...

CAS#:13790-39-1

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4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure

4-(3-bromoanili...

CAS#:171745-13-4

Literature: Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
2-Amino-4,5-dimethoxybenzoic acid structure

2-Amino-4,5-dim...

CAS#:5653-40-7

~%

4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure

4-(3-bromoanili...

CAS#:171745-13-4

Literature: Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
6,7-Dimethoxy-3,4-dihydroquinazoline-4-one structure

6,7-Dimethoxy-3...

CAS#:13794-72-4

~%

4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure

4-(3-bromoanili...

CAS#:171745-13-4

Literature: Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
3-Bromoaniline structure

3-Bromoaniline

CAS#:591-19-5

4-Chloro-6,7-diethoxyquinazoline structure

4-Chloro-6,7-di...

CAS#:162363-46-4

~%

4-(3-bromoanilino)-6,7-diethoxyquinazoline Structure

4-(3-bromoanili...

CAS#:171745-13-4

Literature: Wright, Stephen W.; Hageman, David L.; McClure, Lester D.; Carlo, Anthony A.; Treadway, Judith L.; Mathiowetz, Alan M.; Withka, Jane M.; Bauer, Paul H. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 17 - 21

 Synonyms

compound 56
N-(3-Bromophenyl)-6,7-diethoxyquinazolin-4-amine
4-(3'-bromoanilino)-6,7-diethoxyquinazoline
4-(3-bromoanilino)-6,7-diethoxyquinazoline
4-quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine
4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline
(3-Bromophenyl)-(6,7-diethoxyquinazolin-4-yl)-amine
YXOXHAUUTIOBDA-UHFFFAOYSA
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Chemsrc provides CAS#:171745-13-4 MSDS, density, melting point, boiling point, structure, etc. Its name is 4-(3-bromoanilino)-6,7-diethoxyquinazoline>> amp version: 4-(3-bromoanilino)-6,7-diethoxyquinazoline

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