H-Glu(H-Lys-OH)-OH

Modify Date: 2025-08-25 11:05:15

H-Glu(H-Lys-OH)-OH Structure
H-Glu(H-Lys-OH)-OH structure
 Common Name H-Glu(H-Lys-OH)-OH
CAS Number 17105-15-6 Molecular Weight 275.30200
Density 1.29g/cm3 Boiling Point 610.3ºC at 760mmHg
Molecular Formula C11H21N3O5 Melting Point N/A
MSDS Chinese USA Flash Point 322.9ºC

 Use of H-Glu(H-Lys-OH)-OH


Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration[1].

 Names

Name γ-Glu-ε-Lys
Synonym More Synonyms

 H-Glu(H-Lys-OH)-OH Biological Activity

Description Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration[1].
Related Catalog
References

[1]. Siegfried G Priglinger, et al. Potential Role of Tissue Transglutaminase in Glaucoma Filtering Surgery. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3835-45.

[2]. A M El Nahas, et al. Elevated Epsilon-(Gamma-Glutamyl)lysine in Human Diabetic Nephropathy Results From Increased Expression and Cellular Release of Tissue Transglutaminase.Nephron Clin Pract. 2004;97(3):c108-17.

 Chemical & Physical Properties

Density 1.29g/cm3
Boiling Point 610.3ºC at 760mmHg
Molecular Formula C11H21N3O5
Molecular Weight 275.30200
Flash Point 322.9ºC
Exact Mass 275.14800
PSA 155.74000
LogP 0.66840
Vapour Pressure 1.26E-16mmHg at 25°C
Index of Refraction 1.538

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles31

More Articles
In-vitro digestibility and amino acid composition of soy protein isolate cross-linked with microbial transglutaminase followed by heating with ribose.

Int. J. Food Sci. Nutr. 60 Suppl 7 , 99-108, (2009)

Cross-linked soy protein isolate (SPI) gels were produced via single-treatment of SPI with microbial transglutaminase (MTG) for 5 h or 24 h, or with ribose for 2 h, or via combined-treatments of SPI w...

Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells.

J. Biol. Chem. 279(46) , 47754-62, (2004)

Diabetic nephropathy affects 30-40% of diabetics leading to end-stage kidney failure through progressive scarring and fibrosis. Previous evidence suggests that tissue transglutaminase (tTg) and its pr...

Identification and quantification of epsilon-(gamma-glutamyl)lysine in digests of enzymatically cross-linked leguminous proteins by high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS).

J. Agric. Food Chem. 53(8) , 2830-7, (2005)

A rapid and convenient method for the precise quantification of epsilon-(gamma-glutamyl)lysine isopeptide in lyophilized proteolytic digests of cross-linked plant protein samples was developed. The is...

 Synonyms

6-amino-2-[(4-amino-4-carboxybutanoyl)amino]hexanoic acid
H-Glu(H-Lys-OH)-OH
epsilon-(gamma-Glutamyl)-lysine
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