(1S)-CCR2 antagonist 1

Modify Date: 2025-08-25 10:46:21

(1S)-CCR2 antagonist 1 structure	Common Name	(1S)-CCR2 antagonist 1
	CAS Number	1683534-97-5	Molecular Weight	549.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₂BrF₃N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (1S)-CCR2 antagonist 1

(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].

Name	(1S)-CCR2 antagonist 1

Description	(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> CCR
In Vitro	The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
References	[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.

Molecular Formula	C₂₈H₃₂BrF₃N₂O
Molecular Weight	549.47
InChIKey	QYDUEIJZRKTNKN-NIYJGHKDSA-N
SMILES	CC(C)C1(C(=O)N2CCc3ccc(C(F)(F)F)cc3C2)CCC(NC2CCc3cc(Br)ccc32)C1

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