UK-2A

Modify Date: 2025-08-19 23:23:13

Use of UK-2A

UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity[1][2].

Name	(3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate
Synonym	More Synonyms

Description	UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	UK-2A (0-100 µg/mL; 24, 48, 120 h) 显示出针抗真菌活性，对 R. mucilaginosa IFO 0001 在 24、48、120 小时的 MIC 值分别为 1.56、>100、>100 µg/mL[2]。
References	[1]. Ueki M, et al. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties. J Antibiot (Tokyo). 1996 Jul;49(7):639-43. [2]. Tani K, et al. UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J Antibiot (Tokyo). 2002 Mar;55(3):315-21.

Molecular Formula	C₂₆H₃₀N₂O₉
Molecular Weight	514.52400
Exact Mass	514.19500
PSA	150.35000
LogP	2.20030
InChIKey	MLGCATYQZVMGBG-PBWVOLNLSA-N
SMILES	COc1ccnc(C(=O)NC2COC(=O)C(Cc3ccccc3)C(OC(=O)C(C)C)C(C)OC2=O)c1O

UK-2A

(3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate

Isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester

(3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-di-oxonan-7-yl isobutyrate