SCO-267

Modify Date: 2024-01-11 09:57:54

SCO-267 structure	Common Name	SCO-267
	CAS Number	1656261-09-4	Molecular Weight	614.77
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₆N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SCO-267

SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes[1].

Name	SCO-267

Description	SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
Target	GPR40[1]
In Vitro	SCO-267 (CHO cells) activates the Gαq, Gαs, and Gα12/13 pathways and β-Arrestin Recruitment. SCO-267 is allosteric with fasiglifam and an endogenous ligand[1].
In Vivo	SCO-267 (1 or 10 mg/kg; p.o.) improves insulin sensitivity and exerts sustained glucose-lowering effect[1]. Animal Model: N-STZ rats[1] Dosage: 1 or 10 mg/kg Administration: P.o.; Result: Improved insulin sensitivity and exerted sustained glucose-lowering effect.
References	[1]. Koyama R, et al. Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats. Mol Pharmacol. 2021 Apr;99(4):286-293.

Molecular Formula	C₃₆H₄₆N₄O₅
Molecular Weight	614.77

DC Chemicals Limited
China
Product Name: SCO-267
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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