CGP60474

Modify Date: 2025-08-26 12:08:54

Use of CGP60474

CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.

Name	3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
Synonym	More Synonyms

Description	CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> TGF-beta/Smad >> PKC Research Areas >> Cancer
Target	VEGFR-2:84 nM (IC50) PKC
In Vitro	CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2].
References	[1]. Kuo GH, et al. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46. [2]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005 Jun 24;70(13):5215-20.

Density	1.356g/cm3
Boiling Point	630.6ºC at 760mmHg
Molecular Formula	C₁₈H₁₈ClN₅O
Molecular Weight	355.82100
Flash Point	335.2ºC
Exact Mass	355.12000
PSA	86.19000
LogP	3.22480
Vapour Pressure	9.02E-17mmHg at 25°C
Index of Refraction	1.685
InChIKey	IYNDTACKOAXKBJ-UHFFFAOYSA-N
SMILES	OCCCNc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1
Storage condition	2-8℃

GNF-Pf-88

1-Propanol,3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)

UNII-16IP6G5MLC

CGP60474

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Price: $131/10mM*1mLinDMSO

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