BDM-2

Modify Date: 2024-01-17 19:46:34

BDM-2 Structure
BDM-2 structure
 Common Name BDM-2
CAS Number 1643876-33-8 Molecular Weight 394.50
Density N/A Boiling Point N/A
Molecular Formula C25H30O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BDM-2


BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity[1].

 Names

Name BDM-2

 BDM-2 Biological Activity

Description BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity[1].
Related Catalog
References

[1]. Le Rouzic E, et al. Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors. bioRxiv, 2023: 2023.01. 28.523533.

 Chemical & Physical Properties

Molecular Formula C25H30O4
Molecular Weight 394.50
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