Trastuzumab duocarmazine
Modify Date: 2025-08-26 08:55:12
Trastuzumab duocarmazine structure
|
Common Name | Trastuzumab duocarmazine | ||
|---|---|---|---|---|
| CAS Number | 1642152-40-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trastuzumab duocarmazineTrastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas[1]. |
| Name | Trastuzumab duocarmazine |
|---|
| Description | Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Trastuzumab duocarmazine (SYD985) (0.0001-100 μg/mL, 24 h) 对 HER2- 和 HER2+ 细胞都有杀伤力，与作用于 T-DM1 的 IC50 值为 0.096 μg/mL 相比，对 HER2/NEU3+ 细胞系的杀伤力要高出 7 倍，IC50值为 0.013 μg/mL。更重要的是，在 HER2/NEU1+ 细胞中，它的杀伤力是 T-DM1 的 54 倍[1]。 |
| In Vivo | Trastuzumab duocarmazine (SYD985) (3 mg/kg or 10 mg/kg, i.v., once) 均可以显著抑制肿瘤的生长，延长小鼠的生存周期，具有有效的体内抗肿瘤活性[1]。 |
| References |
| No Any Chemical & Physical Properties |