VU0453379

Modify Date: 2024-04-01 19:13:40

VU0453379 structure	Common Name	VU0453379
	CAS Number	1638646-27-1	Molecular Weight	434.57
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₄N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VU0453379

VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].

Name	VU0453379

Description	VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	EC50: 1.3 μM (GLP-1R)[1]
References	[1]. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7.

Molecular Formula	C₂₆H₃₄N₄O₂
Molecular Weight	434.57

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