LJI308
Modify Date: 2024-01-18 19:02:22
LJI308 structure
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Common Name | LJI308 | ||
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| CAS Number | 1627709-94-7 | Molecular Weight | 368.377 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 486.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H18F2N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 248.1±28.7 °C | |
Use of LJI308LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.IC50 value: 6/4/13 nMTarget: RSK1/2/3in vitro: LJI308 efficiently inhibits RSK activity. LJI308 inhibites S6K1 with an IC50 of 0.8 μM, representing a 200-fold lower inhibition than that of RSK2. LJI308 inhibits MEK4 less than 50% at 10 μMand HIP kinase 1 less than 50% at 1 μM. [1] LJI308 inhibits the growth and survival of TNBC. LJI308 also suppresses the growth of HTRY-LT cells in 3-dimensional soft agar cultures. LJI308 is one of the first potent and effective targeted therapies for TNBC that, unlike currently utilized drugs, exhibits efficacy in eliminating the CSC population. [2] |
| Name | 2,6-Difluoro-4-{4-[4-(4-morpholinyl)phenyl]-3-pyridinyl}phenol |
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| Synonym | More Synonyms |
| Description | LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.IC50 value: 6/4/13 nMTarget: RSK1/2/3in vitro: LJI308 efficiently inhibits RSK activity. LJI308 inhibites S6K1 with an IC50 of 0.8 μM, representing a 200-fold lower inhibition than that of RSK2. LJI308 inhibits MEK4 less than 50% at 10 μMand HIP kinase 1 less than 50% at 1 μM. [1] LJI308 inhibits the growth and survival of TNBC. LJI308 also suppresses the growth of HTRY-LT cells in 3-dimensional soft agar cultures. LJI308 is one of the first potent and effective targeted therapies for TNBC that, unlike currently utilized drugs, exhibits efficacy in eliminating the CSC population. [2] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 486.6±45.0 °C at 760 mmHg |
| Molecular Formula | C21H18F2N2O2 |
| Molecular Weight | 368.377 |
| Flash Point | 248.1±28.7 °C |
| Exact Mass | 368.133636 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.602 |
| Storage condition | -20℃ |
| 2,6-Difluoro-4-{4-[4-(4-morpholinyl)phenyl]-3-pyridinyl}phenol |
| Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]- |
| LJI308 |
| LJI-308 |