RC-3095 acetate
Modify Date: 2025-08-30 10:14:36
RC-3095 acetate structure
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Common Name | RC-3095 acetate | ||
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| CAS Number | 162666-31-1 | Molecular Weight | 1166.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H83N15O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RC-3095 acetateRC-3095 acetate is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist[1]. RC-3095 acetate exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2]. |
| Name | RC-3095 acetate |
|---|
| Description | RC-3095 acetate is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist[1]. RC-3095 acetate exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2]. |
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| Related Catalog | |
| Target |
Bombesin receptor; GRPR[1] |
| In Vivo | RC-3095 impairs aversive but not recognition memory in Wistar male rats[1]. RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA)[2]. Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR[2]. Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model[2] Dosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA; Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model. |
| References |
| Molecular Formula | C58H83N15O11 |
|---|---|
| Molecular Weight | 1166.37 |
| InChIKey | CDMNLOBTPBBPCB-RWWZSYIDSA-N |
| SMILES | CC(=O)O.CC(C)CC(CNC(CC(C)C)C(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C1Cc2c([nH]c3ccccc23)CN1)C(C)C |