6-deoxyjacareubin
Modify Date: 2025-08-25 17:45:18
6-deoxyjacareubin structure
|
Common Name | 6-deoxyjacareubin | ||
|---|---|---|---|---|
| CAS Number | 16265-56-8 | Molecular Weight | 310.30 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 523.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H14O5 | Melting Point | 214-215℃ | |
| MSDS | N/A | Flash Point | 195.8±23.6 °C | |
Use of 6-deoxyjacareubin6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1]. |
| Name | 5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | 6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。 |
| In Vivo | 6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. Animal Model: Male SOD1G93A mice (eight weeks)[1] Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.), every seven days for 1 month Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 523.4±50.0 °C at 760 mmHg |
| Melting Point | 214-215℃ |
| Molecular Formula | C18H14O5 |
| Molecular Weight | 310.30 |
| Flash Point | 195.8±23.6 °C |
| Exact Mass | 310.084137 |
| PSA | 79.90000 |
| LogP | 3.99 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.668 |
| InChIKey | NHNIESSJWQBRJW-UHFFFAOYSA-N |
| SMILES | CC1(C)C=Cc2c(cc3oc4c(O)cccc4c(=O)c3c2O)O1 |
| Hazard Codes | Xi |
|---|
| 5,10-dihydroxy-2,2-dimethylpyrano(3,2-b)xanthen-6(2H)-one |
| 6-Dehydroxyjacareubin |
| 6-Deoxyjacareubin |
| 6-Desoxyjacareubin |
| 5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one |
| Jacareubin,6-deoxy |
| 2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl- |