UNC0379
Modify Date: 2024-01-02 17:04:24
UNC0379 structure
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Common Name | UNC0379 | ||
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| CAS Number | 1620401-82-2 | Molecular Weight | 413.556 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 606.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C23H35N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.5±34.3 °C | |
Use of UNC0379UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases.IC50 value: 7.3±1.0 uMTarget: SETD8 inhibitorUNC0379 is a synthetic small-molecule inhibitor that displays inhibitory activity in multiple biochemical assays and is selective for SETD8 over 15 other methyltransferases. The binding affinity of UNC0379 to SETD8 was determined using biophysical assays such as ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) and is largely consistent with its potency in biochemical assays. |
| Name | 6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine |
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| Synonym | More Synonyms |
| Description | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases.IC50 value: 7.3±1.0 uMTarget: SETD8 inhibitorUNC0379 is a synthetic small-molecule inhibitor that displays inhibitory activity in multiple biochemical assays and is selective for SETD8 over 15 other methyltransferases. The binding affinity of UNC0379 to SETD8 was determined using biophysical assays such as ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) and is largely consistent with its potency in biochemical assays. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 606.3±65.0 °C at 760 mmHg |
| Molecular Formula | C23H35N5O2 |
| Molecular Weight | 413.556 |
| Flash Point | 320.5±34.3 °C |
| Exact Mass | 413.279083 |
| LogP | 2.76 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.606 |
| Storage condition | 2-8℃ |
| 4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]- |
| 6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine |
| UNC0379 |