Pemrametostat (GSK3326595)
Modify Date: 2025-08-21 11:47:23
Pemrametostat (GSK3326595) structure
|
Common Name | Pemrametostat (GSK3326595) | ||
|---|---|---|---|---|
| CAS Number | 1616392-22-3 | Molecular Weight | 452.549 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 760.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H32N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 413.6±32.9 °C | |
Use of Pemrametostat (GSK3326595)GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. |
| Name | GSK3326595 |
|---|---|
| Synonym | More Synonyms |
| Description | GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.2 nM (PRMT5)[1] |
| In Vitro | GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin’s lymphoma[1]. |
| References |
[1]. WO 2016022605 A1 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 760.3±60.0 °C at 760 mmHg |
| Molecular Formula | C24H32N6O3 |
| Molecular Weight | 452.549 |
| Flash Point | 413.6±32.9 °C |
| Exact Mass | 452.253601 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.626 |
| InChIKey | JLCCNYVTIWRPIZ-NRFANRHFSA-N |
| SMILES | CC(=O)N1CCC(Nc2cc(C(=O)NCC(O)CN3CCc4ccccc4C3)ncn2)CC1 |
| Storage condition | -20℃ |
| 6-[(1-Acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide |
| 4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]- |
| EPZ-015938 |