SW IV-134
Modify Date: 2025-08-24 21:54:57
SW IV-134 structure
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Common Name | SW IV-134 | ||
|---|---|---|---|---|
| CAS Number | 1613383-99-5 | Molecular Weight | 871.221 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C51H78N6O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SW IV-134SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52.SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-қB activation and TNFα-dependent cell death. |
| Name | SW IV-134 |
|---|
| Description | SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52.SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-қB activation and TNFα-dependent cell death. |
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| References | 1. Garg G, et al. Mol Cancer. 2014 Mar 7;13:50. 2. Hashim YM, et al. Mol Oncol. 2014 Jul;8(5):956-67. 3. Hashim YM, et al. J Exp Clin Cancer Res. 2017 Jan 17;36(1):14. 4. Oost TK, et al. J Med Chem. 2004;47:4417–4426. |
| Molecular Formula | C51H78N6O6 |
|---|---|
| Molecular Weight | 871.221 |