QZN 34
Modify Date: 2024-02-07 12:23:04
QZN 34 structure
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Common Name | QZN 34 | ||
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| CAS Number | 1612779-02-8 | Molecular Weight | 363.930 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H30ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of QZN 34QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives.QZN 34 prevented S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development.QZN 34 killed planktonic Gram-positive pathogens including S. aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Clostridioides difficile but not Gram-negative bacteria such as P. aeruginosa and Escherichia. coli.QZN 34 eradicated the mixed-species biofilm against mixed S. aureus and P. aeruginosa biofilms when combined with aminoglycoside. |
| Name | QZN 34 |
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| Description | QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives.QZN 34 prevented S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development.QZN 34 killed planktonic Gram-positive pathogens including S. aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Clostridioides difficile but not Gram-negative bacteria such as P. aeruginosa and Escherichia. coli.QZN 34 eradicated the mixed-species biofilm against mixed S. aureus and P. aeruginosa biofilms when combined with aminoglycoside. |
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| References | 1. Ewan J Murray, et al. Cell Chem Biol. 2022 Mar 3:S2451-9456(22)00088-5. |
| Molecular Formula | C20H30ClN3O |
|---|---|
| Molecular Weight | 363.930 |