SC57666
Modify Date: 2024-01-10 15:38:21
SC57666 structure
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Common Name | SC57666 | ||
|---|---|---|---|---|
| CAS Number | 158959-32-1 | Molecular Weight | 316.39000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H17FO2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SC57666SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. |
| Name | 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzenee |
|---|---|
| Synonym | More Synonyms |
| Description | SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. |
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| Related Catalog | |
| Target |
COX-2:26 nM (IC50) |
| In Vitro | SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM)[2]. |
| In Vivo | SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1]. |
| References |
| Molecular Formula | C18H17FO2S |
|---|---|
| Molecular Weight | 316.39000 |
| Exact Mass | 316.09300 |
| PSA | 42.52000 |
| LogP | 5.40470 |
| Storage condition | 2-8℃ |
| 1-fluoro-4-(2-(4-methylsulfonylphenyl)-1-cyclopenten-1-yl)benzene |
| SC-57666 |
| 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]cyclopenten-1-yl] benzene |
| 1-fluoro-4-(2-(4-(methanesulfonyl)phenyl)cyclopent-1-enyl)benzene |
| 1-(4-methanesulphonylphenyl)-2-(4-fluorophenyl)cyclopentene |
| 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene |
| SC57666 |