TAK-603

Modify Date: 2024-01-28 12:00:27

TAK-603 structure	Common Name	TAK-603
	CAS Number	158146-85-1	Molecular Weight	478.50
	Density	1.29g/cm3	Boiling Point	640.7ºC at 760 mmHg
	Molecular Formula	C₂₅H₂₆N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	341.3ºC

Use of TAK-603

TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].

Name	ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
Synonym	More Synonyms

Description	TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	TAK-603 (0, 1, 10 µM; 48 h) 抑制同种异体反应性和 OVA 反应性 BALB/c 小鼠 T 细胞系中的 IFN-γ 的产生，但对 IL-4 产生几乎没有影响 [2].
In Vivo	TAK-603 (6.25 mg/kg；口服；每天) 减少关节炎病变和脾脏中 Thl-型细胞因子的产生[2]。 Animal Model: AA rats[2] Dosage: 6.25 mg/kg Administration: P.o.; daily Result: Inhibited arthritic paw swelling with the inhibition rate of 65% and the IFN-y mRNA expression in the arthritic joint was significantly reduced.
References	[1]. Mizuno M, et al. Syntheses of metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603). Tetrahedron, 2006, 62(37), 8707–8714. [2]. Ohta Y, et al. TAK-603 selectively suppresses Th1-type cytokine production and inhibits the progression of adjuvant arthritis. Immunology. 1997 Sep;92(1):75-83.

Density	1.29g/cm3
Boiling Point	640.7ºC at 760 mmHg
Molecular Formula	C₂₅H₂₆N₄O₆
Molecular Weight	478.50
Flash Point	341.3ºC
Exact Mass	478.18500
PSA	106.82000
LogP	3.75270
Vapour Pressure	2.59E-16mmHg at 25°C
Index of Refraction	1.604

1,2,4-Triazole structure

1,2,4-Triazole

CAS#:288-88-0

N/A structure

N/A

CAS#:153394-50-4

~53%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Takeda Chemical Industries, Ltd. Patent: US5719157 A1, 1998 ;

1,2,4-Triazole structure

1,2,4-Triazole

CAS#:288-88-0

methanol-chloroform structure

methanol-chloroform

CAS#:7285-11-2

N/A structure

N/A

CAS#:153394-50-4

~51%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Takeda Chemical Industries, Ltd. Patent: US5698699 A1, 1997 ;

Ethyl 2-Chloroacetoacetate structure

Ethyl 2-Chloroa...

CAS#:638-07-3

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Mizuno, Masahiro; Inagaki, Atsushi; Yamashita, Makoto; Soma, Norie; Maeda, Yoshiharu; Nakatani, Hiroshi Tetrahedron, 2006 , vol. 62, # 17 p. 4065 - 4070

2,2-Dimethoxy-N-phenylacetamide structure

2,2-Dimethoxy-N...

CAS#:881-70-9

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Mizuno, Masahiro; Inagaki, Atsushi; Yamashita, Makoto; Soma, Norie; Maeda, Yoshiharu; Nakatani, Hiroshi Tetrahedron, 2006 , vol. 62, # 17 p. 4065 - 4070

3,4-Dimethoxyaniline structure

3,4-Dimethoxyaniline

CAS#:6315-89-5

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Mizuno, Masahiro; Inagaki, Atsushi; Yamashita, Makoto; Soma, Norie; Maeda, Yoshiharu; Nakatani, Hiroshi Tetrahedron, 2006 , vol. 62, # 17 p. 4065 - 4070

2-acetylamino-3',4,4'-5-tetramethoxybenzophenone structure

2-acetylamino-3...

CAS#:189001-13-6

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Mizuno, Masahiro; Inagaki, Atsushi; Yamashita, Makoto; Soma, Norie; Maeda, Yoshiharu; Nakatani, Hiroshi Tetrahedron, 2006 , vol. 62, # 17 p. 4065 - 4070

2-amino-4,5,3',4'-tetramethoxybenzophenone structure

2-amino-4,5,3',...

CAS#:153394-55-9

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Baba, Atsuo; Kawamura, Noriaki; Makino, Haruhiko; Ohta, Yoshikazu; Taketomi, Shigehisa; Sohda, Takashi Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5176 - 5182

N/A structure

N/A

CAS#:153394-50-4

~%

TAK-603 Structure

TAK-603

CAS#:158146-85-1

Literature: Mizuno, Masahiro; Inagaki, Atsushi; Yamashita, Makoto; Soma, Norie; Maeda, Yoshiharu; Nakatani, Hiroshi Tetrahedron, 2006 , vol. 62, # 17 p. 4065 - 4070

3-Quinolinecarboxylic acid,4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-,ethyl ester

ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate

ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate

6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester

ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(4H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate

Ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-3-quinolinecarboxylate

4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3