SB-209670

Modify Date: 2025-09-10 18:00:17

SB-209670 structure	Common Name	SB-209670
	CAS Number	157659-79-5	Molecular Weight	520.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₈O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SB-209670

SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty[1].

Name	SB209670
Synonym	More Synonyms

Description	SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
References	[1]. E H Ohlstein, et al. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8052-6.

Molecular Formula	C₂₉H₂₈O₉
Molecular Weight	520.53
InChIKey	UUAVCCWBNUITBB-UPRLRBBYSA-N
SMILES	CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCC(=O)O)C(C(=O)O)C2c1ccc2c(c1)OCO2

SB-209670

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SB-209670
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Purity: 99.24%
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SB-209670

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.