Cloprostenol isopropyl ester

Modify Date: 2024-01-03 01:45:14

Cloprostenol isopropyl ester Structure
Cloprostenol isopropyl ester structure
Common Name Cloprostenol isopropyl ester
CAS Number 157283-66-4 Molecular Weight 466.99500
Density 1.227±0.06 g/cm3 Boiling Point N/A
Molecular Formula C25H35ClO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cloprostenol isopropyl ester


Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM[1][2].

 Names

Name (+)-Cloprostenol isopropyl ester
Synonym More Synonyms

 Cloprostenol isopropyl ester Biological Activity

Description Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM[1][2].
Related Catalog
In Vivo Cloprostenol isopropyl ester (25 μg/kg; i.p.; daily, for 4 weeks; male mice) induces changes in the evolution of the spermatogenesis and spermiogenesis[1]. Cloprostenol isopropyl ester (1 μg, 30 μL; injected into the eye; for 2, 4 and 6 h) causes pupil constriction in the cat. Cloprostenol isopropyl ester has an efficacious ocular hypotensive in the lasered monkey[2]. Animal Model: Male mice (50–80 days)[1] Dosage: 25 μg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Stimulated the androgen synthesis in a time-dependent manner.
References

[1]. Sava A, et, al. Electron microscopic aspects of the effects of certain prostaglandin analogs on mouse testes. Rom J Morphol Embryol. 2015;56(2 Suppl):771-5.

[2]. Hellberg MR, et, al. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S13-33.

 Chemical & Physical Properties

Density 1.227±0.06 g/cm3
Molecular Formula C25H35ClO6
Molecular Weight 466.99500
Exact Mass 466.21200
PSA 96.22000
LogP 4.06200
Water Solubility Insuluble (4.1E-3 g/L) (25 ºC)

 Synonyms

Cloprostenol isopropyl ester
CPG 6112-95