L-159282

Modify Date: 2024-01-02 20:41:36

L-159282 structure	Common Name	L-159282
	CAS Number	157263-00-8	Molecular Weight	524.63300
	Density	1.27g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₈N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of L-159282

L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.

Name	N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]sulfonylbenzamide
Synonym	More Synonyms

Description	L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease
In Vivo	In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1].
References	[1]. Kivlighn SD, et al. In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996. Am J Hypertens. 1995 Jan;8(1):58-66.

Density	1.27g/cm3
Molecular Formula	C₃₀H₂₈N₄O₃S
Molecular Weight	524.63300
Exact Mass	524.18800
PSA	105.82000
LogP	7.10010
Index of Refraction	1.654
Storage condition	2-8℃

mk-996

L-159282