ZK159222
Modify Date: 2024-01-10 11:44:44
ZK159222 structure
|
Common Name | ZK159222 | ||
|---|---|---|---|---|
| CAS Number | 156965-15-0 | Molecular Weight | 512.721 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 646.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C32H48O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 201.1±25.0 °C | |
Use of ZK159222ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) agonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character[1]. |
| Name | ZK159222 |
|---|---|
| Synonym | More Synonyms |
| Description | ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) agonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character[1]. |
|---|---|
| Related Catalog | |
| In Vitro | ZK159222, displayed the profile of a weak VDR agonists that requires an approximate 7-fold higher concentration than of the natural hormone 1α,25-(OH)2D3 to stabilize VDR-RXR heterodimer complex formation on a DR3-type VDRE. ZK159222 was found to belong to the category of 1α,25-(OH)2D3 analogues that stabilize an additional third functional VDR conformation, which has also been described for some agonistic 20-epi analogues. The remaining reporter gene activity that was obtained by a combined treatment of 10 nM 1α,25-(OH)2D3 with 1 μM ZK159222 is close to the partial agonistic activity of 1 μM ZK159222[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 646.3±55.0 °C at 760 mmHg |
| Molecular Formula | C32H48O5 |
| Molecular Weight | 512.721 |
| Flash Point | 201.1±25.0 °C |
| Exact Mass | 512.350159 |
| LogP | 6.46 |
| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
| Index of Refraction | 1.568 |
| Butyl (1S,3R,5Z,7E,22E,24R)-1,3,24-trihydroxy-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-25-carboxylate |
| ZK159222 |
| Cyclopropanecarboxylic acid, 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-, butyl ester |