Ethyl acetoacetate-d3

Modify Date: 2024-01-17 11:35:06

Ethyl acetoacetate-d3 Structure
Ethyl acetoacetate-d3 structure
Common Name Ethyl acetoacetate-d3
CAS Number 1565868-21-4 Molecular Weight 133.16
Density N/A Boiling Point N/A
Molecular Formula C6H7D3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ethyl acetoacetate-d3


Ethyl acetoacetate-d3 is the deuterium labeled Ethyl acetoacetate. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[1][2][3]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[4].

 Names

Name Ethyl acetoacetate-d3

 Ethyl acetoacetate-d3 Biological Activity

Description Ethyl acetoacetate-d3 is the deuterium labeled Ethyl acetoacetate. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[1][2][3]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[5].
References

[1]. Rao M.Uppu, et al. Enantioselective catalytic asymmetric hydrogenation of ethyl acetoacetate in room temperature ionic liquids. Biochemical and Biophysical Research Communications. 1996 Dec; 229(3):764-769.

[2]. Leo F. Salter, et al. A dual‐frequency Belousov Zhabotinskii oscillating reaction with ethyl acetoacetate as organic substrate. substrate. International Journal of Chemical Kinetics. 1982. 14(8), 815–821.

[3]. Iqbal S, et al. 2-Oxo-1,2,3,4-tetrahydropyrimidines Ethyl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies. Med Chem. 2018;14(8):818-830.

[4]. Horne SM, et al. Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm. Lett Appl Microbiol. 2018 Apr;66(4):329-339.  

[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  

 Chemical & Physical Properties

Molecular Formula C6H7D3O3
Molecular Weight 133.16