TP0463518

Modify Date: 2025-08-25 15:39:01

TP0463518 Structure
TP0463518 structure
 Common Name TP0463518
CAS Number 1558021-37-6 Molecular Weight 431.83
Density N/A Boiling Point N/A
Molecular Formula C20H18ClN3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TP0463518


TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

 Names

Name TP0463518

 TP0463518 Biological Activity

Description TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].
Related Catalog
References

[1]. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.

 Chemical & Physical Properties

Molecular Formula C20H18ClN3O6
Molecular Weight 431.83
InChIKey HMMHKGLPKAQOOH-UHFFFAOYSA-N
SMILES O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O
Storage condition 2-8℃
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Chemsrc provides TP0463518(CAS#:1558021-37-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TP0463518 are included as well.>> amp version: TP0463518

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