Emodepside
Modify Date: 2025-08-19 22:36:08
Emodepside structure
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Common Name | Emodepside | ||
|---|---|---|---|---|
| CAS Number | 155030-63-0 | Molecular Weight | 1119.39000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C60H90N6O14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EmodepsideEmodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. |
| Name | emodepside |
|---|---|
| Synonym | More Synonyms |
| Description | Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. |
|---|---|
| Related Catalog | |
| In Vitro | Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes[1]. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min[2]. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside[3]. |
| In Vivo | Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction[4]. |
| References |
[1]. Harder A, et al. Mechanisms of action of emodepside. Parasitol Res. 2005 Oct;97 Suppl 1:S1-10. |
| Molecular Formula | C60H90N6O14 |
|---|---|
| Molecular Weight | 1119.39000 |
| Exact Mass | 1118.65000 |
| PSA | 211.38000 |
| LogP | 5.21960 |
| InChIKey | ZMQMTKVVAMWKNY-YSXLEBCMSA-N |
| SMILES | CC(C)CC1C(=O)OC(Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N(C)C(CC(C)C)C(=O)OC(Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N1C |
| Storage condition | 2-8℃ |
| YZ647Y5GC9 |
| Bay-44-4400 |
| Emodepside [INN] |
| (3S,6R,9S,12R,15S,18R,21S,24R)-4,6,10,16,18,22-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-12,24-bis[(4-morpholin-4-ylphenyl)methyl]-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracosane-2,5,8,11,14,17,20,23-octone |
| Emodepside |
| UNII-YZ647Y5GC9 |
| PF-1022-221 |