Carfilzomib-d8

Modify Date: 2024-01-09 11:55:52

Carfilzomib-d8 structure	Common Name	Carfilzomib-d8
	CAS Number	1537187-53-3	Molecular Weight	727.96
	Density	1.2±0.1 g/cm3	Boiling Point	975.6±65.0 °C at 760 mmHg
	Molecular Formula	C₄₀H₄₉D₈N₅O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	543.8±34.3 °C

Use of Carfilzomib-d8

Carfilzomib-d8 is deuterium labeled Carfilzomib. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

Name	N-[(2S)-2-{[(2H8)-4-Morpholinylacetyl]amino}-4-phenylbutanoyl]-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-phenylalaninamide
Synonym	More Synonyms

Description	Carfilzomib-d8 is deuterium labeled Carfilzomib. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kuhn DJ, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90. [3]. Dasmahapatra G, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011 Sep;10(9):1686-97.

Density	1.2±0.1 g/cm3
Boiling Point	975.6±65.0 °C at 760 mmHg
Molecular Formula	C₄₀H₄₉D₈N₅O₇
Molecular Weight	727.96
Flash Point	543.8±34.3 °C
Exact Mass	727.476013
LogP	6.71
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.551

N-[(2S)-2-{[(2H8)-4-Morpholinylacetyl]amino}-4-phenylbutanoyl]-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-phenylalaninamide

L-Phenylalaninamide, N-[(2S)-2-[[2-(4-morpholinyl-d8)acetyl]amino]-1-oxo-4-phenylbutyl]-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-

Carfilzomib-d8

Use of Carfilzomib-d8

Names

Carfilzomib-d8 Biological Activity

Chemical & Physical Properties

Synonyms