Emtricitabine Degradant-III
Modify Date: 2025-08-27 10:48:00
Emtricitabine Degradant-III structure
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Common Name | Emtricitabine Degradant-III | ||
|---|---|---|---|---|
| CAS Number | 152128-77-3 | Molecular Weight | 263.24600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H10FN3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Emtricitabine Degradant-IIIEmtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection. |
| Name | 4-amino-5-fluoro-1-[(2R,3R,5S)-2-(hydroxymethyl)-3-oxo-1,3-oxathiolan-5-yl]pyrimidin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection. |
|---|---|
| Related Catalog | |
| Target |
Reverse Transcriptase HIV |
| In Vitro | Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1]. |
| References |
| Molecular Formula | C8H10FN3O4S |
|---|---|
| Molecular Weight | 263.24600 |
| Exact Mass | 263.03800 |
| PSA | 127.64000 |
| InChIKey | DMOMZPWPIDCLMB-YGFFCSEESA-N |
| SMILES | Nc1nc(=O)n(C2CS(=O)C(CO)O2)cc1F |
| [2R-(2|A,5|A)]-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone |
| Emtricitabine S-Oxide (Mixture of Diastereomers) |
| 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone |
| [2R-(2|A,5|A)]-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-Oxide |
| Emtricitabine Impurity 2 |
| Emtricitabine Degradant-III |