AC187

Modify Date: 2024-01-02 11:12:00

AC187 structure	Common Name	AC187
	CAS Number	151804-77-2	Molecular Weight	2890.21000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂₇H₂₀₅N₃₇O₄₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AC187

AC 187 is an orally active, potent amylin receptor antagonist (IC50= 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. AC 187 blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. AC 187 increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Name	ac 187
Synonym	More Synonyms

Description	AC 187 is an orally active, potent amylin receptor antagonist (IC50= 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. AC 187 blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. AC 187 increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
Related Catalog	Signaling Pathways >> Others >> Others

Description

Related Catalog

Signaling Pathways >> Others >> Others