Iralukast
Modify Date: 2025-08-25 17:30:43
Iralukast structure
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Common Name | Iralukast | ||
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| CAS Number | 151581-24-7 | Molecular Weight | 710.75600 | |
| Density | 1.37g/cm3 | Boiling Point | 828.7ºC at 760mmHg | |
| Molecular Formula | C38H37F3O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 455ºC | |
Use of IralukastIralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1. |
| Name | 7-[(2S,3E,5Z)-10-(4-acetyl-3-hydroxy-2-propylphenoxy)-1-hydroxy-1-[3-(trifluoromethyl)phenyl]deca-3,5-dien-2-yl]sulfanyl-4-oxochromene-2-carboxylic acid |
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| Synonym | More Synonyms |
| Description | Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1. |
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| Related Catalog | |
| Target |
CysLT1:7.8 (pKi) |
| In Vitro | Both Iralukast and CGP 57698 are able to compete for the two sites labelled by [3H]-LTD4. As in all the G-protein coupled receptors, Iralukast and CGP 57698 do not discriminate between the high and the low affinitystates of the CysLT receptor labelled by LTD4 (Ki1=Ki2=16.6 nM±36% CV and Ki1=Ki2=5.7 nM±19% CV, respectively). Iralukast, displays a slow bindingkinetic, because preincubation (15 min) increases its antagonist potency. Iralukast and CGP 57698 antagonize LTD4-induced contraction of humanbronchi, with pA2 values of 7.77±4.3% CV and 8.51±1.6% CV, respectively, and slopes not significantly different from unity[2]. |
| References |
| Density | 1.37g/cm3 |
|---|---|
| Boiling Point | 828.7ºC at 760mmHg |
| Molecular Formula | C38H37F3O8S |
| Molecular Weight | 710.75600 |
| Flash Point | 455ºC |
| Exact Mass | 710.21600 |
| PSA | 159.57000 |
| LogP | 8.92670 |
| Iralukast |
| UNII-L1E28E0J8F |