Nec-3a

Modify Date: 2025-08-26 00:24:56

Nec-3a structure	Common Name	Nec-3a
	CAS Number	1504558-72-8	Molecular Weight	438.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₈F₄N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nec-3a

Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

Name	Nec-3a

Description	Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase
Target	RIPK1:0.44 μM (IC50)
References	[1]. Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.

Molecular Formula	C₂₁H₁₈F₄N₂O₄
Molecular Weight	438.37

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