Nec-3a

Modify Date: 2025-08-26 00:24:56

Nec-3a Structure
Nec-3a structure
 Common Name Nec-3a
CAS Number 1504558-72-8 Molecular Weight 438.37
Density N/A Boiling Point N/A
Molecular Formula C21H18F4N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nec-3a


Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

 Names

Name Nec-3a

 Nec-3a Biological Activity

Description Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
Related Catalog
Target

RIPK1:0.44 μM (IC50)

References

[1]. Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.  

 Chemical & Physical Properties

Molecular Formula C21H18F4N2O4
Molecular Weight 438.37
InChIKey RPGVJSZQQKMKSB-JLTOFOAXSA-N
SMILES COc1ccc2c(c1)C1=NN(C(=O)CO)C(c3ccc(OC(F)(F)F)c(F)c3)C1CC2
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Chemsrc provides Nec-3a(CAS#:1504558-72-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Nec-3a are included as well.>> amp version: Nec-3a

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