2-MPMDQ

Modify Date: 2025-08-20 19:39:16

2-MPMDQ Structure
2-MPMDQ structure
Common Name 2-MPMDQ
CAS Number 149847-77-8 Molecular Weight 405.49
Density 1.3±0.1 g/cm3 Boiling Point 578.2±60.0 °C at 760 mmHg
Molecular Formula C23H27N5O2 Melting Point N/A
MSDS N/A Flash Point 303.5±32.9 °C

 Use of 2-MPMDQ


2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].

 Names

Name 2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
Synonym More Synonyms

 2-MPMDQ Biological Activity

Description 2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].
Related Catalog
Target

α1-adrenergic receptor:0.37 nM (Ki)

α2-adrenergic receptor:1740 nM (Ki)

References

[1]. J W Chern, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem. 1993 Jul 23;36(15):2196-207.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 578.2±60.0 °C at 760 mmHg
Molecular Formula C23H27N5O2
Molecular Weight 405.49
Flash Point 303.5±32.9 °C
Exact Mass 405.216461
LogP 1.60
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.676

 Synonyms

Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-
2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
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