CYH33 methanesulfonate
Modify Date: 2025-11-21 14:31:22
CYH33 methanesulfonate structure
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Common Name | CYH33 methanesulfonate | ||
|---|---|---|---|---|
| CAS Number | 1494684-33-1 | Molecular Weight | 694.702 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H33F3N8O8S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CYH33 methanesulfonateCYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical |
| Name | CYH33 methanesulfonate |
|---|
| Description | CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical |
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| References | References 1. Haoyue Xiang, et al. Abstract LB-268, AACR, 2018. View Related Products by Target PI3K Solid Tumors |
| Molecular Formula | C25H33F3N8O8S2 |
|---|---|
| Molecular Weight | 694.702 |
| InChIKey | CYWUJTNXNJVGLY-UHFFFAOYSA-N |
| SMILES | COC(=O)Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)c3cc(CN4CCN(S(C)(=O)=O)CC4)cn3n2)cn1.CS(=O)(=O)O |