5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM structure
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Common Name | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM | ||
|---|---|---|---|---|
| CAS Number | 148892-91-5 | Molecular Weight | 588.141 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H14N6Na3O13P3 | Melting Point | 230 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUMGuanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3]. |
| Name | Trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine |
|---|---|
| Synonym | More Synonyms |
| Description | Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3]. |
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| Related Catalog | |
| In Vitro | Guanylyl Imidodiphosphate trisodium (GppNHp) (100 μM) induces the secretion of dense granules from permeabilized platelets in response to calcium ion stimulation, and GTP-Ral enhances the calcium sensitivity of permeabilized platelet dense granule secretion which is inhibited by Sec5-RBD[1]. Guanylyl Imidodiphosphate trisodium (GppNHp) (0.017-333 μM) causes a significant reduction in the lag time required to stimulate adenylate cyclase activity[3]. |
| References |
| Melting Point | 230 °C |
|---|---|
| Molecular Formula | C10H14N6Na3O13P3 |
| Molecular Weight | 588.141 |
| Exact Mass | 587.952454 |
| Storage condition | 20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
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Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.
Biol. Chem. 395(7-8) , 801-12, (2014) As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factor... |
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G proteins.
Trends Biochem. Sci. 17 , 383-387, (1992) The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings ... |
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Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.
Science 252 , 1171-1173, (1991) The signal recognition particle (SRP) directs signal sequence specific targeting of ribosomes to the rough endoplasmic reticulum. Displacement of the SRP from the signal sequence of a nascent polypept... |
| Guanosine, 5'-O-[hydroxy[[hydroxy(phosphonoamino)phosphinyl]oxy]phosphinyl]-, sodium salt (1:3) |
| Trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine |