(+)-EMD 57033
Modify Date: 2024-01-14 19:47:03
(+)-EMD 57033 structure
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Common Name | (+)-EMD 57033 | ||
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| CAS Number | 147527-31-9 | Molecular Weight | 425.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (+)-EMD 57033(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1]. |
| Name | (+)-EMD 57033 |
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| Description | (+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1]. |
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| Related Catalog | |
| Target |
Cardiac troponin C (cTnC)[1] |
| In Vitro | (+)-EMD 57033 (30 μM) recovers the activation and sensitivity of Ca2+ in pig single muscle fibres and reduces VIDD (ventilator-induced diaphragm muscle fibre dysfunction) of [2]. (+)-EMD 57033 (5.0-5.8 μM; 10-15 min) significantly increases the coronary blood flow and myocardial V̇o2 (O2 consumption) in both 100 bpm and 150 bpm heart rates of rabbit heart, with a [Ca2+]0 concentration-dependent manner ([Ca2+]0=1.0 or 2.5 mM)[3]. (+)-EMD 57033 (5.0-5.8 μM; 10-15 min) increases left ventricular (LV) end-diastolic pressure and prolongs relaxation[3]. |
| In Vivo | (+)-EMD 57033 (0.4 or 0.8 mg/kg/min; i.v.drip; over than 20 min) enhances contractility and achieves Ca2+ sensitization in intact failing hearts at substantial energetic savings and without compromise of diastolic function in dogs[4]. Animal Model: Mongrel dogs implanted with a micromanometer in left ventricle (LV) at the apex via lateral thoracotomy[4] Dosage: 0.4 or 0.8 mg/kg/min Administration: Intravenous drip; infused over 20 minutes Result: Enhanced contractility at both doses, with similar changes in CON (conscious dogs) and HF (heart failure dogs) hearts. Decreased the end-diastolic pressure (EDP) and lowered arterial load or preload at 0.8 mg/kg/min. |
| References |
| Molecular Formula | C22H23N3O4S |
|---|---|
| Molecular Weight | 425.50 |