QL47
Modify Date: 2024-01-10 13:48:16
QL47 structure
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Common Name | QL47 | ||
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| CAS Number | 1469988-75-7 | Molecular Weight | 447.488 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 706.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C27H21N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 380.9±32.9 °C | |
Use of QL47QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.IC50 Value: 7 nMTarget: Btkin vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].in vivo: N/A |
| Name | QL47 |
|---|---|
| Synonym | More Synonyms |
| Description | QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.IC50 Value: 7 nMTarget: Btkin vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].in vivo: N/A |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 706.2±60.0 °C at 760 mmHg |
| Molecular Formula | C27H21N5O2 |
| Molecular Weight | 447.488 |
| Flash Point | 380.9±32.9 °C |
| Exact Mass | 447.169525 |
| LogP | 2.50 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.724 |
| Storage condition | 2-8℃ |
| 1-(1-Acryloyl-2,3-dihydro-1H-indol-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one |
| Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)- |
| 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone |