MRT 199665
Modify Date: 2024-01-08 20:07:49
MRT 199665 structure
|
Common Name | MRT 199665 | ||
|---|---|---|---|---|
| CAS Number | 1456858-57-3 | Molecular Weight | 373.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRT 199665MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively; also inhibits AMPKα1/α2 (both IC50=10 nM), MARK1/2/3/4 (both IC50=2 nM), NUAK1/2 (IC50=3/120 nM), and MELK (IC50=29 nM); elevates IL-10 production by inducing the dephosphorylation of CREB-regulated transcriptional coactivator 3 (CRTC3), increases LPS-stimulated IL-10 production and greatly suppressed proinflammatory cytokine secretion (IL-6, IL-12, and TNF) in macrophages. |
| Name | MRT 199665 |
|---|
| Description | MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively; also inhibits AMPKα1/α2 (both IC50=10 nM), MARK1/2/3/4 (both IC50=2 nM), NUAK1/2 (IC50=3/120 nM), and MELK (IC50=29 nM); elevates IL-10 production by inducing the dephosphorylation of CREB-regulated transcriptional coactivator 3 (CRTC3), increases LPS-stimulated IL-10 production and greatly suppressed proinflammatory cytokine secretion (IL-6, IL-12, and TNF) in macrophages. |
|---|---|
| References | References 1. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. 2. Darling NJ, et al. Biochem J. 2017 Feb 15;474(4):521-537. 3. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target Salt Inducible Kinase (SIK) |
| Molecular Formula | C18H19N3O4S |
|---|---|
| Molecular Weight | 373.43 |