PBD dimer-2

Modify Date: 2025-08-25 09:43:35

PBD dimer-2 structure	Common Name	PBD dimer-2
	CAS Number	145325-57-1	Molecular Weight	560.64100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₆N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PBD dimer-2

PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–drug conjugates (ADCs), and it can be used for the research of cancer[1][2].

Name	1,1'-<(pentane-1,5-diyl)dioxy>bis<(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo<1,2-c><1,4>benzodiazepin-5-one>
Synonym	More Synonyms

Description	PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–drug conjugates (ADCs), and it can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42(27):8232-9. [2]. Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42(27):8232-9.

[2]. Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622.

Molecular Formula	C₃₁H₃₆N₄O₆
Molecular Weight	560.64100
Exact Mass	560.26300
PSA	102.26000
LogP	3.71990

1,1-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4] benzodiazepine-5-one]

1,1'-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one]

1,1'-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[1,2-c][1,4]benzodiazepin-5-one]

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PBD dimer-2

Use of PBD dimer-2

Names

PBD dimer-2 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.