Musk tibetene

Modify Date: 2025-08-22 11:21:31

Musk tibetene Structure
Musk tibetene structure
Common Name Musk tibetene
CAS Number 145-39-1 Molecular Weight 266.293
Density 1.2±0.1 g/cm3 Boiling Point 391.0±42.0 °C at 760 mmHg
Molecular Formula C13H18N2O4 Melting Point N/A
MSDS N/A Flash Point 174.6±20.7 °C

 Use of Musk tibetene


Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line[1][2].

 Names

Name 1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
Synonym More Synonyms

 Musk tibetene Biological Activity

Description Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line[1][2].
Related Catalog
In Vitro Musk tibetene reveals no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2[1]. Musk tibetene reveals a cell-transforming potential that showed a dose-dependent response in our host-mediated assay system[2].
References

[1]. Kevekordes S, et al. Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Toxicol Lett. 1997 Mar 14;91(1):13-7.

[2]. Apostolidis S, et al. Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. Anticancer Res. 2002 Sep-Oct;22(5):2657-62.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 391.0±42.0 °C at 760 mmHg
Molecular Formula C13H18N2O4
Molecular Weight 266.293
Flash Point 174.6±20.7 °C
Exact Mass 266.126648
PSA 91.64000
LogP 4.68
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.544
InChIKey MINYPECWDZURGR-UHFFFAOYSA-N
SMILES Cc1c(C)c([N+](=O)[O-])c(C(C)(C)C)c([N+](=O)[O-])c1C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ7220000
CHEMICAL NAME :
Benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl-
CAS REGISTRY NUMBER :
145-39-1
BEILSTEIN REFERENCE NO. :
2000732
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H18-N2-O4
MOLECULAR WEIGHT :
266.33
WISWESSER LINE NOTATION :
WNR B1 C1 D1 ENW FX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2783 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

 Safety Information

HS Code 2904209090

 Customs

HS Code 2904209090
Summary 2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

5-tert-Butyl-4,6-dinitro-1,2,3-trimethylbenzene
1-tert-butyl-4,3,5-trimethyl-2-amino-6-nitrobenzene
1,2,3-Trimethyl-5-(2-methyl-2-propanyl)-4,6-dinitrobenzene
EINECS 205-651-6
Musk tibetine
1-tert-butyl-3,4,5-trimethyl-2,6-dinitro-benzene
Musk tibetene
Musk Tebetine
Nitromusk tibetene
1-tert-Butyl-3,4,5-trimethyl-2,6-dinitrobenzene
Benzene, 1- (1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
2-tert-Butyl-1,3-dinitro-4,5,6-trimethylbenzene
Benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
Tibetene musk
1-t-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
musk tibeten
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