Mivebresib

Modify Date: 2024-01-02 07:16:38

Mivebresib structure	Common Name	Mivebresib
	CAS Number	1445993-26-9	Molecular Weight	459.466
	Density	1.5±0.1 g/cm3	Boiling Point	608.9±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₉F₂N₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	322.0±34.3 °C

Use of Mivebresib

Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.

Name	N-[4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
Synonym	More Synonyms

Description	Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Research Areas >> Cancer
Target	IC50: 1.5 nM (BET)[1]
In Vitro	Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins[1].
References	[1]. EJ Faivre et al. Abstract 4694: ABBV-075, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo

Density	1.5±0.1 g/cm3
Boiling Point	608.9±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₉F₂N₃O₄S
Molecular Weight	459.466
Flash Point	322.0±34.3 °C
Exact Mass	459.106445
LogP	3.91
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.647
Storage condition	-20℃

N-[4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide

N-[4-(2,4-Difluorphenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethansulfonamid

N-[4-(2,4-Difluorophénoxy)-3-(6-méthyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phényl]éthanesulfonamide

Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-

Mivebresib

ABBV-075

DC Chemicals Limited
China
Product Name: Mivebresib(ABBV-075）
Price: $600.0/100mg $1100.0/250mg $2050.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Mivebresib suppliers

Price: $121/10mM*1mLinDMSO

Reference only. check more Mivebresib price

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3

Mivebresib

Use of Mivebresib

Names

Mivebresib Biological Activity

Chemical & Physical Properties

Synonyms