(1R)-IDH889

(1R)-IDH889 structure	Common Name	(1R)-IDH889
	CAS Number	1429179-08-7	Molecular Weight	436.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₅FN₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (1R)-IDH889

(1R)-IDH889 is the inactive isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].

Name	(1R)-IDH889

Description	(1R)-IDH889 is the inactive isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.

Molecular Formula	C₂₃H₂₅FN₆O₂
Molecular Weight	436.48
InChIKey	JDCYIMQAIKEACU-DNVCBOLYSA-N
SMILES	Cc1cc(-c2cnc(C(C)Nc3nccc(N4C(=O)OCC4C(C)C)n3)nc2)ccc1F

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(1R)-IDH889

Use of (1R)-IDH889

Names

(1R)-IDH889 Biological Activity

Chemical & Physical Properties

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