IDF-11774

Modify Date: 2024-02-01 18:47:50

IDF-11774 Structure
IDF-11774 structure
Common Name IDF-11774
CAS Number 1429054-28-3 Molecular Weight 368.51
Density N/A Boiling Point N/A
Molecular Formula C23H32N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IDF-11774


IDF-11774 is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM. IDF-11774 has been approved as a clinical candidate for a phase I study.

 Names

Name IDF-11774

 IDF-11774 Biological Activity

Description IDF-11774 is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM. IDF-11774 has been approved as a clinical candidate for a phase I study.
Related Catalog
Target

IC50: 3.65 μM (HIF-1)[1]

In Vitro IDF-11774 is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM in cancer cell line. IDF-11774 has been approved as a clinical candidate for a phase I study. Human umbilical vascular endothelial cells (HUVECs) treated with IDF-11774 show reduced capillary network formation on Matrigel. IDF-11774 treatment leads to reduced mRNA expression of GLUT1 and pyruvate dehydrogenase kinase 1 (PDK1). In addition, intracellular ATP levels are significantly reduced in the presence of IDF-11774 and are affected to a greater degree under low glucose conditions (5.5 mM)[1].
In Vivo Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model[1].
Animal Admin Female Balb/c nude mice are used in this study. Cancer cells are injected subcutaneously into 4- to 6-week-old female Balb/c nude mice to generate tumors (5 mice per group). When the tumors grow to 100 mm3, IDF-11774 is administered orally (per oral) or intravenously for 15 days. Tumor volumes (V) are determined using the following equation: V (mm3)=(length×width×height)×0.5. Percentage tumor growth inhibition (%TGI) values are calculated for each treatment group versus the control[1].
References

[1]. Ban HS, et al. The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. Cell Death Dis. 2017 Jun 1;8(6):e2843.

 Chemical & Physical Properties

Molecular Formula C23H32N2O2
Molecular Weight 368.51
Storage condition -20℃
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: IDF-11774
  • Price: $550.0/100mg $950.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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Price: ¥973/10 mM * 1 mL in DMSO

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